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- Pentadecapeptide Bpc 157 [email protected]
Pentadecapeptide Bpc 157
Alias: Booly Protection Compound 15, Pentadecapeptide, BPC 157
CAS: 137525-51-0
Sequence: Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
MF: C62H98N16O22
MW: 1419.53552
Purity: 99%
Specification: 2mg/vial
Appearance: White Lyophilized Powder
Place of Origin: China
Standard: USP
Method of Analysis: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.
packing:as requirments
Product Description:
BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.
FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.
BPC 157 (Body Protection Compound-157) is a pentadecapeptide made up of 15 amino acids. The amino acids sequence in BPC 157 is similar to a portion of the human BPC amino acid sequence. Human BPC is found in the gastric juice. Experiments have shown that BPC 157 enhances the healing of wounds, including tendons wounds such as transected Achilles tendons of rats. The aim of this study was to investigate the probable mechanism that BPC 157 utilizes to accelerate the healing process in an injured tendon. The study used two group of tendon explants of which one group was cultured in a BPC 157-containing medium while the other group was cultured in a medium lacking BPC 157. These cultures were thereafter examined for tendon fibroblasts outgrowths. Such outgrowths indicated tendon regeneration.The results revealed that the explants' outgrowth was significantly accelerated in the culture containing BPC 157 as compared to the culture lacking BPC 157. Also, a MTT assay did show that BPC 157 does not directly affect cellular proliferation in a culture of rat-derived Achilles tendon. However, results also showed that BPC 157 significantly increased the survival of cells under oxidative stress. Furthermore, the Transwell filter migration assay showed that BPC 157 significantly increased in-vitro fibroblast migration in a dose-dependent fashion. Moreover, BPC 157 accelerated the dispersal of the fibroblasts in culture dishes in a dose-dependent manner.
Product Application:
BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon.
This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay.
Function:
BPC 157-treated cells was significantly increased under the H(2)O(2) stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered.
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(1) Zhuhai Shuangbojie Technology Co.,Ltd is a steroids peptides manufacturer with its own lab and factory. The purity of our product is tested by our quality department before it is shipped to our clients. Mostly steroids are 99% purity and approved by SGS,CTI and ITS.
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- MK-2866/Ostarine/Enobosarm [email protected]
MK-2866/Ostarine/Enobosarm
CAS:841205-47-8
MF:C19H14F3N3O3
MW:389.3279696
Product Categories:Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Hormone Drugs;SARMs(Selective androgen receptor modulator)
Appearance:Almost white or white powder
Purity:99.59%
UsageFunction:New generation supplements for gaining mass and cutting edges
Nonsteroidal selective androgen receptor modulator (SARM) used in the treatment of osteoporosis and muscle wasting in animal models.
A potential compound for the treatment of hypoactive sexual desire disorder.
Descriptions :
Ostarine, also known as MK-2866 is a SARM (selective androgen receptor module) created by GTx to avoid and treat muscle wasting. It can later on be a cure for avoiding atrophy (total wasting away of a body part), cachexia, sarcopenia and Hormone or Testosterone Replacement Therapy.
This type of SARM cannot only retain lean body mass but as well as increase it. Ostarine is often mistaken as S1 but S1 was created earlier and is no longer going through more expansion.
Ostarine is a potent and tissue-selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wasting and osteoporosis. These patent products for research purposes only use. Ostarine (GTx-024, MK-2866, Enobosarm, S-22) is an orally bioavailable nonsteroidal selective androgen receptor modulator. Therefore, ostarine can be used for treatment of conditions such as muscle wasting and osteoporosis.
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- Andarine [email protected]
Andarine
Synonym: S-4, GTx-007
CAS No.: 401900-40-1
M.F.: C19H18F3N3O6
M.W.: 441.36
Assays: 99%
Appearance: White crystalline powder
Molecular mass 441.357 g/mol
Usage:
Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound.
In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.
This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.
Usage An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.
Application :
S-4 is designed for treating conditions such as muscle wasting, osteoporosis and
benign prostatic hypertrophy, using the non-steroidal androgen antagonist bicalutamide
as a lead compound.
As an orally active partial agonist for androgen receptors, S-4 is effective in not only
maintaining lean body mass but actually increasing it.
SARMS such as S4 can cause muscle growth in the same manner as steroids, however
unlike testosterone and other anabolic steroids, SARMS (as nonsteroidal agents) do not
produce the growth effect on prostate and other secondary sexual organs.
The typical dose for cutting is 50 mg for a cycle of 6 to 8 weeks. The cycle should include using the product daily for 5 days and then taking 2 days off for the duration. Tasking the dose every day for the duration of the cycle can result in changes to vision.
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- MK-677( Ibutamoren) [email protected]
MK-677( Ibutamoren)
Synonyms: Ibutamoren, CHEMBL13817, S1151_Selleck, MK-677
CAS No.: 159752-10-0
Molecular Weight: 624.77
Molecular Formula: C28H40N4O8S2
Purity: 99%
Package: Be packed according to the customer requirements and packaging specifications.
Appearance: White crystalline powder
Storage; Store at -20° C
Specificity: MK-677 selectively binds GH secretagogue receptors in certain tissues.
Purity: >99% (HPLC analyzed).
Stability: Store at at 20 °C in dry place until the expiration date.
Source: Chemical Synthesis
Half-life: 24 hours
MK-677( Ibutamoren) Usage
active growth secretagpgie , Ibutamoren mesylate (mk-677) Effective for age related fraity Active secretago
MK-677( Ibutamoren) Introduction
Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191) is a non-
peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor 1 (IGF-1), but without affecting cortisol levels.It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency,and human studies have shown it to increase both muscle mass and bone mineral density,making it a promising therapy for the treatment of frailty in the elderly.It also alters metabolism of body fat and so may have application in the treatment of obesity
Our commitment:
1. Quality assurance
With our years of experience, advanced technology and continuous research, our quality is
to fully meet the needs of the market to meet the requirements ofcustomers, many
customers use our products, we believe that the product is very good. Whether it is a
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Our mode of transport is taken according to each country's situation is different
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- Lgd-4033 [email protected]
Lgd-4033
Synonyms: Ligandrol
CAS: 1165910-22-4
MF: C14H12F6N2O
MW: 338.2482992
Apperance: White Crystalline Powder
Description:
LGD-4033 is rapidly increasing in popularity, as it has shown to be the strongest and most anabolic-like SARM in existence up to this point. SARMS are quite different from steroids in terms of their makeup, lack of side effects and recovery time. SARMS can be run much longer than oral steroids.
They are non-methylated and don't pressure the liver. Although the results are not as drastic as some steroids, they are much cleaner, more keepable and have several properties that are extremely desirable that steroids may not be able to provide.
Application:
LGD can be used for bulking, recomposition and cutting. It possesses the ability to add size while still reducing body fat, akin to primobolan. Another excellent characteristic it possesses is that it can be ran up to 12 weeks, whereas most orals can only be used for 4-6 week time periods. LGD produces steady gains throughout the entire 12 weeks, and it provides a user with an overall sense of well being where you feel excellent throughout the entire time of use. It has anabolic properties without the anabolic side effects.
LGD-4033 also takes effect very quickly and will generally start to show results in the first week of use. In addition, it has shown to increase endurance, which will allow for more output during training, resulting in more gains being made. All these benefits make LGD ideal for any user because it provides an excellent kick-start and has an affinity to produce quality gains that show to be very clean but still substantial.
Dosage:
LGD-4033 should be dosed at 10 mg day, taken orally, once a day in the morning. LGD should be ran 8-12 weeks, with 12 weeks being ideal. A perfect combination for fat loss is LGD-4033 with Andarine (S-4).
Attention:
LGD can cause slight suppression, but nothing comparable to the suppression shown from steroid use and it can be mitigated with the use of HGGenerate on cycle. I find LGD suppression to be mild at best and very easy to recover from.
Popular SARM For Sale:
Andarine S-4 / GTx-007 CAS: 401900-40-1
Ostarine / MK-2866 / GTx-024 CAS: 841205-47-8
Ligandrol / LGD-4033 CAS: 1165910-22-4
Cardarine / GW-501516 CAS: 317318-70-0
RAD140 / Testolone CAS: 118237-47-0
YK11 CAS: 431579-34-9
MK-677 / Ibutamoren CAS: 159752-10-0
SR9009 / Stenabolic CAS: 1379686-30-2
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- GW-501516 [email protected]
GW-501516
Another name: Cardarine; Free Acid; GSK-516
CAS: 317318-70-0
MF: C21H18F3NO3S2
MW: 453.5
MP: 134-136°C
Appearance:white solid
Lossing On Drying:≤0.5%
Ignition Residue:≤0.1%
Heavy Metal:≤20PPm
GW501516 is the name of a Glaxo Wellcome drug (the GW stands for the company and the number is that of the product). It is also known as GW-501,516, GW1516, GSK-516).
GW-501516 is a selective agonist with high affinity and it is very potent. Various studies on this PPAR receptor in lab rats indicates that it regulates the various proteins that the body uses for energy. Rats with high fat and low metabolism were given the product and they were able to lose weight and to increase overall energy levels.
GW-501516 Uses:
GW-501516 has many benefits but has two primary uses. The most common use of GW consists of the extreme amount of endurance and recovery increase.
The other main use of GW-501516 is to aid in fat loss. GW-501516 has shown to melt away fat at a rapid pace.
GW-501516 Dosing Timing:
GW-501516 also has a very long half life, so it can be dosed once a day or split 12 hours apart. The most effective method of dosing is to take it in one serving, 30 minutes prior to working out. On non workout days, once a day dosing in the morning is the best method. If a split dosage is used, 10-12 hour splits are optimal.
The Benefits of GW 501516:
GW 501516 is the "ultimate endurance enhancer" - used by athletes or anyone who competes
1. Improved energy - so you can push harder in the gym
2. Lesser recovery time
3. Melts fat without losing muscle (non-catabolic) - especially in problem areas (e.g. stomach, lower abs, thighs)
4. One of the cleanest energies - not a stimulant = no crashing or anxieties
5. Ability to run longer and harder (builds up overtime)
6. Able to improve in areas you didn't know you could push through
7. Versatile - can be used with a bulking or cutting stack
8. Increase in overall sense of health
9. Can be used for 12 weeks with little to no side effects (non-methylated, no toxicity)
Right Dosage for Cardarine:
Regular dosage of Cardarine is 10 to 20 mg per day. 10 mg a day is aimed for endurance (as well as 20 mg a day). The higher the dosage the more you're targeting towards the fat loss aspect, but 10 mg is perfect.
20 mg/day is more than enough (no need to exceed). Expect to experience more intense endurance and fat burning when taking this amount.
You can take it once a day or split the dosage (in the morning and then 10-12 hours after). Best taken 30-45 minutes before a workout.
Stacking GW 501516:
Stacking Cardarine means running it in combination with other compounds. What makes Cardarine stand out is it can be used with almost anything (cutting, bulking or recomping).
1. Bulking - clean up your gains and make that bulk more cleaner while letting you hold on to your size
2. Cutting - totally optimal when it comes to weight loss while holding on to muscle mass
3. Recomping - perfect for building lean muscle and losing fat
Non-methylated, non-toxic. No need to worry about liver and lipid problems.
Most common stack is Cardarine with Tren which can impact your cardiovascular.
GW 501516 balances this problem. It also stacks well with other SARMS especially with SARMS triple stack -MK 2886, S-4 and GW 501516.You need to cycle off every 8-12 weeks so your body won't get used to it or it won't be effective. Don't use it too long.
Our commitment:
1. Quality assurance
With our years of experience, advanced technology and continuous research, our quality is
to fully meet the needs of the market to meet the requirements ofcustomers, many
customers use our products, we believe that the product is very good. Whether it is a
powder, or liquid, yes, we all know, our liquid better.
2. Safe transportation
Our mode of transport is taken according to each country's situation is different
transportation, while our packaging, according to the latest customs situation,constantly
updated, improved our packaging, we guarantee that you receive it within 3-5 to your
product.
3. The product diversity
Our products are powders and liquids, yes, brothers, the effect of the liquid is very good, but many people do not use liquid, so you are very lucky, you buy our powder, we can tell you
the method of making the liquid If you buy a liquid, we will tell you how to filter. We
absolutely guarantee that you can very safely use our products
4. High quality service : Our goods packing will not contain any hormone information and
can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle
close rate area, we also have a new way to get through the customs. We also have
completely re-send policy to some areas.
[email protected]
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- SR9009 [email protected]
SR9009
Synonyms:Ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-
1-carboxylate
CAS No.: 1379686-30-2
Molecular formular: C20H24ClN3O4S
Molecular Weight: 437.94
Appearance: White powder
Purity: 99%
Application: SR9009 increase exercise endurance and loss weight.
SR9009 Description:
A new compound called SR9009 increases metabolism, fat burning, and muscle growth in the lab. Scientists at The Scripps Research Institute (TSRI) have successfully tested a drug, called SR9009,in mice that kickstarts metabolism and results in increased muscle development.Essentially, it's an exercise regime in a pill.
SR9009 alters the metabolic profile of skeletal muscle in a manner similar to the changes observed[in] animals [that] are endurance trained. Basically, the drug sends a signal to the muscle to tell it to modify its metabolism.
Half of the mice studied showed improved running endurance in terms of both time and distance.What was clearly interesting was that a small, drug-like molecule could increase metabolic rate in skeletal muscle and increase exercise endurance
SR9009 Not Just a "Diet" Pill
There's no way to sugarcoat it-though many have tried-maintaining a healthy weight can be difficult. Because it's hard, many have tried "miracle" weight-loss pills and other quick fixes for something that ultimately requires a lifestyle change. Many over-the-counter diet and weigh-loss pills are unregulated and may contain dangerous ingredients.
SR9009, however, isn't like appetite suppressants, laxatives, or "fat blockers." And you won't find SR9009 in the ingredient lists of protein powders or exercise supplements.
The difference between SR9009 and other diet pills is in its chemistry. SR9009 is not an appetite suppressant-as many weight-loss drugs are-and directly works by increasing the metabolic rate of muscle.
Your metabolism speeds up and slows down naturally during the day, meaning that sometimes food is used for energy and sometimes it's stored as fat. By re-synching a dysfunctional metabolic clock,
SR9009 ensures that food and excess fat are used as energy.
SR9009 is one of a pair of compounds developed at TSRI by Burris and his team. The drug binds to Rev-erbα, a natural protein in the body that influences lipid and glucose metabolism in the liver, inflammatory responses, and fat-storing cells. By binding to
Rev-erbα, SR9009 can kickstart metabolism with another pleasant side-effect: increased muscle strength.
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- SR9011 [email protected]
SR9011
Synonyms:Ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-
1-carboxylate
CAS No.: 1379686-30-2
Molecular formular: C20H24ClN3O4S
Molecular Weight: 437.94
Appearance: White powder
Purity: 99%
Application: SR9011 increase exercise endurance and loss weight.
Usage:reduce mass fat
Packing:1kg/foil bag
SR9011Usage:
A new compound called SR9011 increases metabolism, fat burning, and muscle growth in the lab.Scientists at The Scripps Research Institute (TSRI) have successfully tested a drug, called SR9011,in mice that kickstarts metabolism and results in increased muscle development.Essentially, it's an exercise regime in a pill.
SR9011 alters the metabolic profile of skeletal muscle in a manner similar to the changes observed [in] animals [that] are endurance trained. Basically, the drug sends a signal to the muscle to tell it to modify its metabolism.
Half of the mice studied showed improved running endurance in terms of both time and distance. What was clearly interesting was that a small, drug-like molecule could increase metabolic rate in skeletal muscle and increase exercise endurance
SR9011 Not Just a "Diet" Pill
There's no way to sugarcoat it-though many have tried-maintaining a healthy weight can be difficult. Because it's hard, many have tried "miracle" weight-loss pills and other quick fixes for something that ultimately requires a lifestyle change. Many over-the-counter diet and weigh-loss pills are unregulated and may contain dangerous ingredients. SR9011, however, isn't like appetite suppressants, laxatives, or "fat blockers." And you won't find SR9011 in the ingredient lists of protein powders or exercise supplements.
The difference between SR9009 and other diet pills is in its chemistry. SR9011 is not an appetite suppressant-as many weight-loss drugs are-and directly works by increasing the metabolic rate of muscle. Your metabolism speeds up and slows down naturally during the day, meaning that sometimes food is used for energy and sometimes it's stored as fat. By re-synching a dysfunctional metabolic clock, SR9011 ensures that food and excess fat are used as energy.
SR9011 is one of a pair of compounds developed at TSRI by Burris and his team. The drug binds to Rev-erb,a natural protein in the body that influences lipid and glucose metabolism in the liver, inflammatory responses, and fat-storing cells. By binding to Rev-erb, SR9011 can kickstart metabolism with another pleasant side-effect: increased muscle strength.
Description:
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB- with an EC50 ~790 nM and REV-ERB-with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB- and REV-ERB- play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
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RAD140
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Description :
RAD140 is a nonsteroidal selective androgen receptor modulator, or SARM, that resulted from an internal drug discovery program that began in 2005.
RAD 140 is a SARM that is designed to act as if the tissues of the body are getting a good dose of testosterone without the unwanted side effects of anabolic steroids. It has been shown to enhance speed, stamina and endurance during workouts as well as increase muscular gains within shorter periods of time.
Application :
RAD140 has demonstrated potent anabolic activity on muscle and bone in preclinical studies and has completed 28-day preclinical toxicology studies in both rats and monkeys. Because of its high anabolic efficacy, receptor selectivity, potent oral activity and long duration half-life, we believe that RAD140 has clinical potential in a number of indications where the increase in lean muscle mass and/or bone density is beneficial, such as treating the weight loss due to cancer cachexia, muscle frailty and osteoporosis, and also in the treatment of breast cancer.
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